• Login
    • Join
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Manufacturing
    • Markets
    • Top 10 Orthopedic Device Firms
    • Buyers' Guide
    • Events
    • More
  • Magazine
  • News
  • Exclusives
  • Manufacturing
  • Markets
  • Top 10 Orthopedic Device Firms
  • Buyers' Guide
  • Events
  • Current & Past Issues
    Features
    Departments
    Columns
    Editorial
    Digital Edition
    Subscribe Now
    Advertise Now
    Editorial Guidelines
    eNewsletter Archive
    Top Features
    From Nitinol to Nanotubes: A Materials Science Roundtable

    In Good Repair: Trauma Technologies Under Review

    Anxious Undertones: A Review of 2019

    Automated Analysis Advantages for Part Validation

    Tried and True Metalworking
    Breaking News
    Certifications
    Clinical Trials
    Device Approvals & Patents
    Financial & Deals
    International
    Market Data & Trends
    OEM News
    People
    Product & Service Releases
    Products
    Quality, Recalls & Risk
    Regulatory & Legal
    Supplier & Contract Mfg.
    Live From Shows
    Top News & Features
    Orthofix Appoints New Spine Business Leader

    Viant to Halt EtO Sterilization at Michigan Plant by End of Year

    Synaptive Medical's Modus V Expands Into Spine Market

    3D-Printed Graftless Bone Transplants Go to Clinical Trials

    CrossRoads Extremity Systems Acquires Implant Systems from Surgical Frontiers
    3-D Printing/Additive Mfg.
    Assembly & Automation
    Biocompatibility & Testing
    Clean Room
    Coatings/Surface Modification
    Contract Manufacturing
    Design
    Extrusion
    Finishing
    Forging & Casting
    Instruments, Cases & Trays
    International/Offshoring
    Laser Processing
    Materials
    Machining & Tooling
    Molding
    Packaging & Sterilization
    Prototyping
    Research & Developement
    Software & Quality
    Staffing, Training & Prof. Dev.
    Supply Chain

    3D-Printed Graftless Bone Transplants Go to Clinical Trials

    CrossRoads Extremity Systems Acquires Implant Systems from Surgical Frontiers

    Micro Spine Implant Could Restore Standing and Walking

    RTI Surgical Appoints New Division Leaders

    From Nitinol to Nanotubes: A Materials Science Roundtable
    Biologics
    Bracing/Prosthetics
    Extremities
    Imaging
    Instruments
    Large Joint
    MIS/Robotics
    Spine/Neurology
    Trauma/Sports
    Top Markets
    Molybdenum-Rhenium Biomaterial: Something ‘MoRe’?

    New Exoskeleton Shoulders Rehab Burden for Stroke Patients

    Repairing Knee Cartilage Defects with the Patient's Own Cells

    Compamed 2019 Preview Report

    Straightening Out a Spinal Device’s De Novo Pathway
    Companies
    Categories
    Company Capabilities
    White Papers
    Add New Company
    International Buyers Guide Companies
    ARCH Medical Solutions

    Edge International/Supra Alloys

    Hammill Medical

    NN Life Sciences

    Orchid Orthopedic Solutions
    Industry Events
    Webinars
    • Magazine
      • Current & Past Issues
      • Features
      • Editorial
      • Departments
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • Companies
      • Categories
      • Company Capabilities
      • White Papers
      • Add Your Company
    • Manufacturing
      • 3-D Printing/Additive Mfg.
      • Assembly & Automation
      • Biocompatibility & Testing
      • Clean Room
      • Coatings/Surface Modification
      • Contract Manufacturing
      • Design
      • Extrusion
      • Finishing
      • Forging & Casting
      • Instruments, Cases & Trays
      • International/Offshoring
      • Laser Processing
      • Materials
      • Machining & Tooling
      • Molding
      • Packaging & Sterilization
      • Prototyping
      • Research & Developement
      • Software & Quality
      • Staffing, Training & Prof. Dev.
      • Supply Chain
    • Markets
      • Biologics
      • Bracing/Prosthetics
      • Extremities
      • Imaging
      • Instruments
      • Large Joint
      • MIS/Robotics
      • Spine/Neurology
      • Trauma/Sports
    • Top 10 Orthopedic Device Firms
    • Online Exclusives
    • Slideshows
    • Videos
    • Webinars
    • Events
      • Industry Events
    • Live from Show Event
    • About Us
      • About Us
      • Contact Us
      • Privacy Policy
      • Terms of Use
      • Advertise With Us
    Breaking News

    Rheumatoid Arthritis Patients' Joint Replacement Frequency Halved Between 1997-2010

    New data suggests biological therapy not the only influencing factor.

    Rheumatoid Arthritis Patients
    Related CONTENT
    • Corin Group Launches Unity Knee With EquiBalance at AAOS 2018 Meeting
    • Pilot Trial to Evaluate First Bioelectronic Device to Treat Rheumatoid Arthritis
    • Flare-Responsive Hydrogel Developed to Treat Arthritis
    • Sterilization Breach at Colorado Hospital Put Orthopedic Patients at Risk of HIV, Hepatitis
    • RTI Surgical Reaches 8 Million Biologic Implant Milestone
    European League Against Rheumatism06.15.18
    The results of two studies presented today at the Annual European Congress of Rheumatology (EULAR 2018) investigate joint replacement procedures in rheumatoid arthritis (RA) patients.1,2 The first study demonstrates that joint replacement procedures have significantly reduced in RA patients in the past decade1 and the second investigates the impact of biologic therapies on this change using the British Society for Rheumatology Biologics Registry for Rheumatoid Arthritis (BSRBR/RA).2
     
    "We welcome these results demonstrating such a dramatic reduction of joint replacements in RA patients in recent years," said Professor Robert Landewé, Chairperson of the Scientific Programme Committee, EULAR. "It's also very interesting to see data relating specifically to the impact of biological treatments on this outcome given the breadth of progress in the management of RA over the same time period."
     
    Joint Replacement Surgery Halved in Rheumatoid Arthritis Patients Between 1997-2010.1
    The retrospective cohort study examined data from around one million people between 1997 and 2010 using administrative healthcare data. Results demonstrate a striking reduction of 51.9 percent (p<0.001) in joint replacement surgery in RA patients between 1997 and 2010.1
     
    The number of joint replacements in matched controls increased by 31.9 percent (p=0.002) over the 13 years, although remained significantly less than in RA patients at both time points (4.78 percent vs. 0.47 percent in 1997 and 2.30 percent vs. 0.62 percent in 2010). Rates of cardiac interventions did not change significantly over time in either group suggesting the changes observed in joint replacement surgery were due to improvements in the treatment of RA rather than access to surgical procedures.1
     
    "Literature to date has reported inconsistent findings," said Dr. John Hanly, Professor of Medicine (Rheumatology) and Pathology at Dalhousie University and attending staff rheumatologist at the Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada. "However, our results add significant evidence to show a clear reduction in joint replacement surgery in RA patients, most likely due to improvements in medical management over the last few decades."
     
    Cases of RA were identified using a method previously validated in the same data set.3 Each case was matched by age and gender to four randomly selected controls. The number of RA cases increased from 3,913 (0.42 percent) to 4,911 (0.52 percent) over the study, the mean age changed from 56.7 to 60.1 years and the proportion of females from 70.8 to 73.9 percent. Annual frequency of joint replacement surgery as well as coronary artery interventions was compared.1
     
    Impact of Biological Therapy on Rate of Joint Replacement Procedures.2
    The management of RA has progressed significantly over the last 25 years from providing relief of symptoms to regimens that impact disease activity.4 This evolution has been multi-factorial, however it is widely recognized that the introduction of biological therapy with tumor necrosis factor inhibitors (TNFi) in the late 1990s revolutionized treatment.4,5,6,7 Furthermore, recent research from the UK and Denmark has demonstrated a decline in the incidence of joint replacements for RA patients directly following the introduction of TNFi.8,9 However, findings presented today suggest that, although TNFi use may reduce the need for total hip replacement (THR) in older and more severe RA patients, no association was found in younger or less severe patients. Neither was there an association in rates of total knee replacement (TKR) or other joint replacement.2
     
    "The use of biologic therapies has been routinely offered as an explanatory factor for the reduction in rates of joint replacement over recent years," said Samuel Hawley, University of Oxford. "Our study offers some support for this in that a reduction in hip replacement procedures was observed in older patients on TNFi, although our results also suggest additional factors are likely to be involved. For example, the drive for earlier diagnosis/treatment and increased prescription rates of conventional synthetic disease-modifying antirheumatic drugs. It's important to highlight that we used an observational study design and that despite our best efforts to address confounding factors, these may still partly explain our findings".
     
    The study analyzed the differences between RA patients who were TNFi or conventional synthetic disease-modifying antirheumatic drug (csDMARD) users in a 1:1 propensity score matched cohort of 19,116 patient records using the BSRBR/RA data. In the full study population, investigators found no significant association between TNFi use and THR or TKR. However, there was a significant reduction of THR by 40 percent in those over 60 years taking TNFi (HR 0.60 [CI:0.41-0.87]) and THR rate was cut by a quarter in TNFi users when analyses were restricted to more severe patients (DAS>5.1), although this didn't reach significance (HR 0.74 [CI 0.51-1.05]). No significant findings were found relating TNFi users with TKR procedures.2
     
    References
    1 Hanly JG, Lethbridge L, Skedgel C. Change in frequency of arthroplasty surgery in rheumatoid arthritis: A 13 year population health study. EULAR 2018; Amsterdam: Abstract SAT0077.
    2 Hawley S, Cordtz R, Dreyer L, et al. Impact of TNF inhibitors on need for joint replacement in patients with rheumatoid arthritis: A matched cohort analysis of UK biologics registry data. EULAR 2018; Amsterdam: Abstract OP0116.
    3 Hanly JG, Thompson K, Skedgel C. The use of administrative healthcare databases to identify patients with Rheumatoid Arthritis. Open Access Rheumatol. 2015;7:69-75.
    4 Upchurch KS, Kay J. Evolution of treatment for rheumatoid arthritis. Rheumatology (Oxford). 2012;51(suppl 6):vi28-36.
    5 Scott DL. Biologics-based therapy for the treatment of rheumatoid arthritis. Clin Pharmacol Ther. 2012;91(1):30-43.
    6 Feldmann M, Williams RO, and Paleolog E. What have we learnt from targeted anti-TNF therapy? Ann Rheum Dis. 2010;69:97-9.
    7 Curtis JR and Singh JA. Use of biologics in rheumatoid arthritis: current and emerging paradigms of care. Clin Ther. 2011;33:679-707.
    8 Cordtz RL, Hawley S, Prieto-Alhambra D, et al. Incidence of hip and knee replacement in patients with rheumatoid arthritis following the introduction of biological DMARDs: an interrupted time-series analysis using nationwide Danish healthcare registers. Ann Rheum Dis. 2018;77(5):684-9.
    9 Hawley S, Cordtz R, Dreyer L, et al. Association between NICE guidance on biologic therapies with rates of hip and knee replacement among rheumatoid arthritis patients in England and Wales: An interrupted time-series analysis. Semin Arthritis Rheum. 2018;47(5):605-10.
    Related Searches
    • tkr
    • total knee replacement
    • medical
    • joint replacement
    Suggested For You
    Orig3n Initiates Osteoarthritis Cartilage Regeneration as First Cell Therapy Program Orig3n Initiates Osteoarthritis Cartilage Regeneration as First Cell Therapy Program
    First U.S. Surgery Using Medacta First U.S. Surgery Using Medacta's M.U.S.T. SI Joint Screw System for Sacroiliac Joint Fusion
    Early Indicators of Bone Loss After Hip Replacement Discovered Early Indicators of Bone Loss After Hip Replacement Discovered
    Going Stemless Going Stemless
    Bioelectronic Medicine Gets on Arthritis’ Last Nerve Bioelectronic Medicine Gets on Arthritis’ Last Nerve
    Shouldering Growth: An Examination of the Extremities Implant Sector Shouldering Growth: An Examination of the Extremities Implant Sector
    Doctor Charged With $240 Million Healthcare Fraud and International Money Laundering Scheme Doctor Charged With $240 Million Healthcare Fraud and International Money Laundering Scheme
    U.S. Orthopedic Devices Market to Witness Massive Growth Over 2017-2024 U.S. Orthopedic Devices Market to Witness Massive Growth Over 2017-2024
    U.S. Pilot Trial to Evaluate First Bioelectronic Device to Treat Rheumatoid Arthritis U.S. Pilot Trial to Evaluate First Bioelectronic Device to Treat Rheumatoid Arthritis
    RTI Surgical Reaches 8 Million Biologic Implant Milestone RTI Surgical Reaches 8 Million Biologic Implant Milestone
    Sterilization Breach at Colorado Hospital Put Orthopedic Patients at Risk of HIV, Hepatitis Sterilization Breach at Colorado Hospital Put Orthopedic Patients at Risk of HIV, Hepatitis
    Flare-Responsive Hydrogel Developed to Treat Arthritis Flare-Responsive Hydrogel Developed to Treat Arthritis
    Pilot Trial to Evaluate First Bioelectronic Device to Treat Rheumatoid Arthritis Pilot Trial to Evaluate First Bioelectronic Device to Treat Rheumatoid Arthritis
    Corin Group Launches Unity Knee With EquiBalance at AAOS 2018 Meeting Corin Group Launches Unity Knee With EquiBalance at AAOS 2018 Meeting

    Related Breaking News

    • Spine/Neurology
      Orthofix Appoints New Spine Business Leader

      Orthofix Appoints New Spine Business Leader

      Kevin Kenny was previously VP of U.S. sales for Spine and Biologics at Medtronic.
      Business Wire 12.05.19

    • Packaging & Sterilization
      Viant to Halt EtO Sterilization at Michigan Plant by End of Year

      Viant to Halt EtO Sterilization at Michigan Plant by End of Year

      EGLE had been investigating over the past year and issued Viant several violations for inadequate capture and control of ethylene oxide emissions.
      Michigan Department of Environment, Great Lakes, and Energy (EGLE) 12.04.19

    • Spine/Neurology
      Synaptive Medical

      Synaptive Medical's Modus V Expands Into Spine Market

      Modus V’s robotic arm moves automatically based on the positions of tracked surgical instruments.
      Business Wire 12.04.19


    • 3-D Printing/Additive Mfg. | Biologics | Materials
      3D-Printed Graftless Bone Transplants Go to Clinical Trials

      3D-Printed Graftless Bone Transplants Go to Clinical Trials

      ADAM is piloting the use of ceramics and polymer in 3D-printed bone implants, able to be produced at commodity prices.
      PR Newswire 12.04.19

    • Extremities
      CrossRoads Extremity Systems Acquires Implant Systems from Surgical Frontiers

      CrossRoads Extremity Systems Acquires Implant Systems from Surgical Frontiers

      The add-on acquisition furthers CrossRoads' strategy to build a market-leading company in the high-growth orthopedic extremities sector.
      PR Newswire 12.04.19

    • Spine/Neurology
      Micro Spine Implant Could Restore Standing and Walking

      Micro Spine Implant Could Restore Standing and Walking

      Hair-like electrical wires send electrical signals to trigger networks that already know how to do the hard work.
      University of Alberta Faculty of Medicine & Dentistry 12.03.19


    • Spine/Neurology
      RTI Surgical Appoints New Division Leaders

      RTI Surgical Appoints New Division Leaders

      Terry Rich, experienced spine leader, named president, Global Spine; Olivier Visa elevated to president, Global OEM.
      GlobeNewswire 12.03.19

    • KCI Introduces Solution for Challenging Surgical Locations

      KCI Introduces Solution for Challenging Surgical Locations

      Company's latest technology targets post-operative incisions and surrounding soft tissue.
      Business Wire 12.03.19

    • EOS Imaging Receives FDA 510(k) Clearance for Next-Gen Imaging System

      EOS Imaging Receives FDA 510(k) Clearance for Next-Gen Imaging System

      EOSedge will be unveiled at the RSNA Annual Meeting.
      Business Wire 12.02.19


    • Large Joint
      mediCAD is Now Officially a Medical Device in Japan

      mediCAD is Now Officially a Medical Device in Japan

      The product is an orthopedic planning solution for hip, knee, shoulder, hand, leg, or spine surgery.
      mediCAD Hectec GmbH 12.02.19

    • Imaging
      New Generation Imaging System Launched in Europe and Canada

      New Generation Imaging System Launched in Europe and Canada

      EOS Imaging will unveil its EOSedge at the upcoming Radiological Society of North America (RSNA) 2019 Annual Meeting.
      Business Wire 11.26.19

    • Software & Quality
      Survey Identifies Challenges to Improving Product Development Processes

      Survey Identifies Challenges to Improving Product Development Processes

      81% of medical device companies are not using tools designed for the medical device industry in their quality management processes.
      PRWeb 11.26.19

    • Extremities
      Arthrosurface Introduces the SpiralUp TCL Allograft System

      Arthrosurface Introduces the SpiralUp TCL Allograft System

      Joint-preserving allograft addresses ankle instability and benefits the entire musculoskeletal system.
      Arthrosurface Inc. 11.26.19

    •  Exactech Acquires Italian Distributor

      Exactech Acquires Italian Distributor

      The deal gives Exactech direct operations in eight global markets with distribution in more than 35 countries.
      Businesswire 11.25.19

    • Spine/Neurology
      FDA Clears Expanded Multi-Level Use of NuVasive

      FDA Clears Expanded Multi-Level Use of NuVasive's CoRoent Small Interlock System

      The product is an anterior cervical interbody fusion system for use in adult patients with cervical disc degeneration and/or cervical spinal instability.
      PR Newswire 11.22.19


    Breaking News
    • Orthofix Appoints New Spine Business Leader
    • Viant to Halt EtO Sterilization at Michigan Plant by End of Year
    • Synaptive Medical's Modus V Expands Into Spine Market
    • 3D-Printed Graftless Bone Transplants Go to Clinical Trials
    • CrossRoads Extremity Systems Acquires Implant Systems from Surgical Frontiers
    View Breaking News >
    CURRENT ISSUE

    November/December 2019

    • From Nitinol to Nanotubes: A Materials Science Roundtable
    • In Good Repair: Trauma Technologies Under Review
    • Anxious Undertones: A Review of 2019
    • View More >
    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    International Scientific Society Calls for Omega-3 Blood Testing in Future Research
    Pharmactive Affron Saffron May Help Relieve Depression Symptoms
    Warmer Temperatures Could Lead to Concerning Levels of Arsenic in Rice
    Coatings World

    Latest Breaking News From Coatings World

    Cristo Rey High School Educator Named 2019 Axalta All-Pro Teacher of the Year
    Michelman Makes United Way of Greater Cincinnati’s List of Top 25 Corporate Campaigns
    BCF: Coatings Industry Reports Record Improvement in Waste, Recycling, Accident Rates
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    FDA OKs Roche's Nasal Swab MRSA Test
    Philips & Paige to Deliver Clinical-Grade AI Applications to Pathology Labs
    Eye Test for Parkinson's Gains Breakthrough Designation
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Almac Awarded $1M BMGF Grant
    Vivera Pharma, Parexel Ink Clinical Services Agreement
    MedPharm Triples Capacity at RTP Site
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    WWP Wins Three NJPEC Awards
    Cat-Themed Beauty Collection to Launch in Japan
    Pantone Names Classic Blue the 2020 Color of the Year
    Happi

    Latest Breaking News From Happi

    Lip Lab Opening in Brooklyn
    Raining Rose Expands Exec Team
    Scott’s Sells Personal Care Production Site
    Ink World

    Latest Breaking News From Ink World

    ePac Flexible Packaging Expands into Asia Pacific Market
    Haney, HP Developing Sustainable Fashion Packaging for Heron Preston
    Addipel Moves to New HQ, Expands Production Facility
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    HP teams with Haney for sustainable packaging
    Tags & Labels Printing adds Heidelberg’s Versafire EP
    Austrian converter installs first Nilpeter press
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Thrace to Relocate U.S. Capacity
    FiltXPO Speaker Line-Up Announced
    Nölken Incorporates Sustainable Wipes Packaging
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Orthofix Appoints New Spine Business Leader
    Viant to Halt EtO Sterilization at Michigan Plant by End of Year
    Synaptive Medical's Modus V Expands Into Spine Market
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    IDTechEx Show! Announces Graphene Award Winner
    OE-A Continues to Bring Future of Printed Electronics to CES 2020
    Avancis, Smit Thermal, HZB, CNRS, Solliace Team for Higher Efficiencies in CIGS

    Copyright © 2019 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.