PR Newswire11.19.20
NuVasive Inc., the leader in spine technology innovation, focused on transforming spine surgery with minimally disruptive, procedurally integrated solutions, has launched Cohere XLIF, the first Porous PEEK interbody brought to market for use in eXtreme Lateral Interbody Fusion (XLIF) and X360 surgeries. Cohere XLIF is a key addition to NuVasive's Advanced Materials Science (AMS) implant portfolio, consisting of proprietary surface and structural technologies, and is designed for bone in-growth while maintaining the imaging and mechanical properties favored in smooth PEEK and titanium coated PEEK interbody devices.
In conjunction, the company also launched the Cohere XLIF AMS plate, a low profile anti-migration plate that allows for up to two points of fixation. The plate provides an additional solution at the discretion of the surgeon, particularly in multi-stage procedures, that can be placed before or after insertion of the Cohere XLIF interbody.
"Cohere XLIF provides surgeons with a porous-surface implant designed to promote stability and improved early fusion rates over smooth PEEK and allograft," said Sanjay Khurana, spine surgeon at LA Spine and Orthopedic Institute in Los Angeles. "Combined with Cohere XLIF, the Cohere XLIF AMS plate equips surgeons with additional technology when pathologic features call for it and gives confidence in a patient's path to returning to normal activities."
The Porous PEEK technology in Cohere XLIF has been recently studied head to head in cervical spine fusion against smooth PEEK and structural allograft bone. Patients treated with Porous PEEK had significant improvements in disability index and pain scores as early as six weeks post-operatively, compared to those treated with the standard implants.1 Highlights of the Cohere XLIF technology include:
"NuVasive's Cohere XLIF implant is another example of how we are combining expertise in lateral implant design with our clinically validated porous surface technology," said Massimo Calafiore, executive vice president, Global Business Units, at NuVasive. "These new offerings strengthen NuVasive's AMS portfolio and equip surgeons with best-in-class technology that procedurally integrate with XLIF and X360 procedures to enable better patient outcomes in spine surgery."
References
1 Hill CP, Strenge KB. Early clinical outcomes comparing porous PEEK, smooth PEEK, and structural allograft interbody devices for anterior cervical discectomy and fusion. J Spine Neurosurg 2019;8(1):1-7.
2 Torstrick FB, Lin ASP, Gall K, et al. Porous PEEK improves the bone-implant interface compared to plasma-sprayed titanium coating on PEEK. Biomaterials 2018;185:106-16.
3 Evans NT, Torstrick FB, Safranski DL, et al. Local deformation behavior of surface porous polyether-ether-ketone. J Mech Behav Biomed Mater 2017;65:522-32.
4 Torstrick FB, Klosterhoff BS, Westerlund LE, et al. Impaction durability of porous polyether-ether-ketone (PEEK) and titanium-coated PEEK interbody fusion devices. Spine J 2018;18:857-65.
5 Carpenter RD, Klosterhoff BS, Torstrick FB, et al. Effect of porous orthopaedic implant material and structure on load sharing with simulated bone ingrowth: A finite element analysis comparing titanium and PEEK. J Mech Behav Biomed Mater 2018;80:68-76.
In conjunction, the company also launched the Cohere XLIF AMS plate, a low profile anti-migration plate that allows for up to two points of fixation. The plate provides an additional solution at the discretion of the surgeon, particularly in multi-stage procedures, that can be placed before or after insertion of the Cohere XLIF interbody.
"Cohere XLIF provides surgeons with a porous-surface implant designed to promote stability and improved early fusion rates over smooth PEEK and allograft," said Sanjay Khurana, spine surgeon at LA Spine and Orthopedic Institute in Los Angeles. "Combined with Cohere XLIF, the Cohere XLIF AMS plate equips surgeons with additional technology when pathologic features call for it and gives confidence in a patient's path to returning to normal activities."
The Porous PEEK technology in Cohere XLIF has been recently studied head to head in cervical spine fusion against smooth PEEK and structural allograft bone. Patients treated with Porous PEEK had significant improvements in disability index and pain scores as early as six weeks post-operatively, compared to those treated with the standard implants.1 Highlights of the Cohere XLIF technology include:
- Cellular Response: As shown in in-vitro studies, Porous PEEK elicits a significantly enhanced osteogenic cell response compared to smooth PEEK and titanium-coated PEEK.2
- Osseointegration: Porous PEEK supports improved implant stability through bone in-growth and has demonstrated greater than three times the integration strength of smooth solid PEEK and titanium-coated PEEK implants in preclinical testing.2
- Durability: Porous PEEK implants maintain high porosity under conditions that replicate clinical loading and resist abrasion damage and delamination under impacted insertion conditions.3,4
- Stiffness: With material stiffness similar to bone, Porous PEEK implants reduce stress shielding and the associated risk of subsidence, compared with stiffer titanium implants.5
"NuVasive's Cohere XLIF implant is another example of how we are combining expertise in lateral implant design with our clinically validated porous surface technology," said Massimo Calafiore, executive vice president, Global Business Units, at NuVasive. "These new offerings strengthen NuVasive's AMS portfolio and equip surgeons with best-in-class technology that procedurally integrate with XLIF and X360 procedures to enable better patient outcomes in spine surgery."
References
1 Hill CP, Strenge KB. Early clinical outcomes comparing porous PEEK, smooth PEEK, and structural allograft interbody devices for anterior cervical discectomy and fusion. J Spine Neurosurg 2019;8(1):1-7.
2 Torstrick FB, Lin ASP, Gall K, et al. Porous PEEK improves the bone-implant interface compared to plasma-sprayed titanium coating on PEEK. Biomaterials 2018;185:106-16.
3 Evans NT, Torstrick FB, Safranski DL, et al. Local deformation behavior of surface porous polyether-ether-ketone. J Mech Behav Biomed Mater 2017;65:522-32.
4 Torstrick FB, Klosterhoff BS, Westerlund LE, et al. Impaction durability of porous polyether-ether-ketone (PEEK) and titanium-coated PEEK interbody fusion devices. Spine J 2018;18:857-65.
5 Carpenter RD, Klosterhoff BS, Torstrick FB, et al. Effect of porous orthopaedic implant material and structure on load sharing with simulated bone ingrowth: A finite element analysis comparing titanium and PEEK. J Mech Behav Biomed Mater 2018;80:68-76.