AAOS News: Successful Trial for CyMedica Orthopedics’ e-vive

CyMedica Orthopedics, the combined digital health and muscle strengthening therapy developer, announced statistically significant, positive results from a randomized, controlled trial which will be presented at the 2019 American Academy of Orthopedic Surgeons meeting. This clinical trial evaluated the effectiveness of the company’s patented e-vive neuromuscular electrical stimulation and patient engagement system for the enhanced rehabilitation of patients undergoing total knee replacement. 
 
The clinical trial results measuring 66 total knee replacement patients released today demonstrate an earlier return to function and increase in quadriceps strength in patients treated with e-vive neuromuscular electrical stimulation (NMES) versus the standard of care, according to researchers at Cleveland Clinic. Statistically significant improvements were shown with these patients, including a clinically significant 12.9 percent increase in quadriceps strength at the 3 week post-operative point (a critical period of time where patients commonly experience a substantial loss of quadriceps strength, 29 percent loss for the standard of care patients in this trial), and increased TUG (Timed Up and Go) test times at both the 6 and 12 week postoperative points, further supporting previous publications representing NMES as an effective method for quadriceps strengthening for knee osteoarthritis and surgical rehabilitation.
 
“We are incredibly pleased to share the results of this clinical trial which reaffirm the effectiveness of the e-vive solution for TKA patients,” said Rob Morocco, president and CEO, CyMedica Orthopedics. “At CyMedica, we are focused on empowering patients throughout their entire journey of knee osteoarthritis, from the early onset of disease to post-surgical rehabilitation. This is accomplished by providing advanced muscle stimulation solutions that foster patient engagement and improve outcomes.”
 
“The results of this trial demonstrate that pre- and post-surgical muscle strengthening and neuromuscular electrical stimulation therapy was shown to be a significant component for patient rehabilitation to achieve quadriceps strength and an earlier return to activity. Combined with the digital health patient engagement features of the device, patients were able to actively participate in more productive rehabilitation following total knee replacement surgery,” said Carlos Higuera-Rueda, M.D., Orthopaedic Surgeon at Cleveland Clinic and Primary Investigator.