Advita Ortho’s Next-Generation Knee Replacement Platform Debuts in Japan

The first clinical use of Advita Ortho’s next-generation knee replacement platform has taken place in Japan, combining Activit-E polyethylene technology in the Truliant knee system with the latest iteration of Advita GPS surgical navigation system and Newton balancing intelligence.

Hiroshi Watanabe, M.D., Ph.D., performed the initial procedures at the Tokorozawa Hakushokai Hospital in Japan, marking the platform’s first clinical use.

“Every patient presents a unique combination of anatomy, soft-tissue characteristics and functional expectations,” Dr. Watanabe said. “Having real-time information about alignment and balance throughout the procedure helps me make more informed decisions and tailor the surgery to each patient.”

At the platform’s core is Activit-E polyethylene technology, a highly crosslinked vitamin E-stabilized bearing material developed through years of materials science research. Designed to deliver low wear while maintaining the strength and toughness required for knee replacement, Activit-E reflects Advita’s commitment to advancing implant materials for the long-term demands of modern joint replacement.

“These first cases demonstrate how advanced implant materials, surgeon-controlled guidance and dynamic balancing intelligence can work together in a unified workflow to provide surgeons with actionable information throughout the procedure and support an efficient, personalized approach to knee replacement,” Advita Ortho CEO Aurelio Sahagun stated. “We’re pleased to introduce these new technologies in Japan, where surgeons have consistently been early adopters of innovations that advance patient care.”

Combined with surgeon-controlled navigation through GPS and Newton balancing intelligence, the Advita technology suite provides real-time feedback during total knee surgery to help surgeons assess alignment, soft-tissue balance, and other factors before final implantation.

“Our goal with Activit-E was to advance polyethylene technology without compromising the characteristics surgeons value most,” commented Orhun Muratoglu, Ph.D., director of the Harris Orthopaedics Laboratory at Massachusetts General Hospital. “By combining highly crosslinked polyethylene with vitamin E stabilization, we developed a material engineered to achieve low wear while preserving the mechanical strength and durability needed for long-term implant performance.”

Following the initial launch in Japan, Advita plans to expand availability in additional global markets.

Advita Ortho specializes in high-quality implants and integrated surgical technologies powered by data, artificial intelligence, and machine learning. The company is based in Gainesville, Fla.